Slide background MOLECULAR MED DRY-LAB COMBICHEM Expertise Image
1.CGH
2. M-FISH
3.G-BANDING

1. Expression
micro-arrays
2. Chip
REPEATABLE PATTERNS (KNOCK DOWN ASSESSMENT) Expertise Image DRUGABLE TARGETS Expertise Image (LOCATION ASSESSMENT)
MOAB

COMBI-CHEM

STAPLE
MOLECULE
Expertise Image CANDIDATE LIGANDS
Slide background MOLECULAR MED DRY-LAB COMBICHEM BIOCHEMICAL ASSAY DEFINITION LIGAND/INHIBITOR
VS TARGET PROTEIN AFFINITY AND IC50
FOR SMW LIPINSKI RULES OF 5 Expertise Image ELISA Expertise Image REJECTED SPR Expertise Image REJECTED QUENCER Expertise Image OPTIMIZATION Expertise Image Expertise Image LEADING COMPOUND (IF IC50<=1uM) (IF 10uM>=IC50>1uM)
Slide background MOLECULAR MED DRY-LAB COMBICHEM CELLULAR ASSAY LEADING COMPOUND Expertise Image FLOW CYTOMETRY Expertise Image REJECTED VIABILITY ASSAYS Expertise Image CANDIDATE DRUG BIOCHEMICAL ASSAYS Expertise Image Expertise Image OPTIMIZATION (IF lC50<=1uM) (IF IC50>1uM)